John 2:25

And needed not that any should testify of man: for he knew what was in man.

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• Omniscience

There was no need for Jesus to be educated about human nature or the opinions of others. Regardless of who He spoke with, He knew exactly what each person needed to hear and what they needed to know. Hence, verse 24 indicates that He did not trust all those who claimed to follow Him in Jerusalem. Throughout history, Jesus has proven to be able to reach people at the exact moment they need it.
As the psalmist reminds us, God knows each of us deeply. The Lord knows when we sit down and when we rise up. Despite being far away, he is aware of our thoughts. Our paths are scrutinized by Him since He knows our every step. Even before we utter a word, God already knows what we will say. Yes, the Lord knows all things.
No man can instruct Jesus about anything, including what lies in a man's heart. As the image of the invisible God, who is the exact reflection of His glory and the unalterable representation of His nature, Jesus is aware of everything and knows everything.

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  John 3:13

  And no man hath ascended up to heaven, but he that came down from heaven, even the Son of man which is in heaven.

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  Hebrews 1:3

  Who being the brightness of his glory, and the express image of his person, and upholding all things by the word of his power, when he had by himself purged our sins, sat down on the right hand of the Majesty on high;

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  Luke 2:4

  And Joseph also went up from Galilee, out of the city of Nazareth, into Judaea, unto the city of David, which is called Bethlehem; (because he was of the house and lineage of David:)

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  John 1:14

  And the Word was made flesh, and dwelt among us, (and we beheld his glory, the glory as of the only begotten of the Father,) full of grace and truth.

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